Haemophilus influenzae b-vaccination: the urgency for timely vaccination.
Identifieur interne : 000564 ( Main/Exploration ); précédent : 000563; suivant : 000565Haemophilus influenzae b-vaccination: the urgency for timely vaccination.
Auteurs : R. Von Kries [Allemagne] ; O. Böhm ; A. WindfuhrSource :
- European journal of pediatrics [ 0340-6199 ] ; 1997.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Allemagne.
English descriptors
- KwdEn :
- MESH :
- geographic , epidemiology : Germany.
- epidemiology : Influenza, Human.
- prevention & control : Influenza, Human.
- Analysis of Variance, Case-Control Studies, Child, Preschool, Female, Haemophilus influenzae, Humans, Immunization Schedule, Immunization, Secondary, Infant, Logistic Models, Male, Odds Ratio.
Abstract
UNLABELLED
In Germany the annual number of systemic Haemophilus influenzae cases in unvaccinated children aged 3-60 months has recently been exceeded by the number of cases in children vaccinated at least once with the PRP-D, HbOC or OMP vaccines, which until 1995 have almost exclusively been used for H. influenzae b (Hib) vaccination. Most of the vaccinated children however could already have had more vaccinations at onset of disease. How much does an age-related suboptimal vaccination status increase the risk for systemic H. influenzae infections? A case control study was performed in West Germany. Cases with systemic H. influenzae infections were ascertained between 7/92 and 8/ 94 with an ongoing active hospital surveillance programme. Six age-matched population controls per case were recruited at random. Only vaccinated cases and controls were included in the study. The main exposure analysed in this study was suboptimal vaccination at censoring; for censoring ages (age at disease onset in cases and corresponding age in matched controls) > 6 months: one vaccination in 1st year only; > 18 months: two (three for combined vaccines with Hib + DT or DPT in one syringe) vaccinations in the 1st year of life but no booster vaccination. Suboptimal vaccination for age increased the risk for systemic H. influenzae infections by a factor of 4.74 (95%-CI 2.17-10.34). Following adjustment for confounders the odds ratio was 4.39 (95%-CI 1.74-11.07). Subgroup analyses showed that this risk was not related to the type of vaccine used. The risk for "no booster vaccination" in children aged > 18 months appeared even greater than the risk associated with one vaccination in the 1st year only.
CONCLUSIONS
On schedule and complete Hib vaccinations are essential for an optimal effectiveness of Hib vaccination programmes. Booster vaccinations between 12 and 18 months are important if the PRP-D, HbOC and OMP vaccines are used for primary vaccination.
DOI: 10.1007/s004310050601
PubMed: 9128812
Affiliations:
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Windfuhr</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1997">1997</date><idno type="RBID">pubmed:9128812</idno><idno type="pmid">9128812</idno><idno type="doi">10.1007/s004310050601</idno><idno type="wicri:Area/Main/Corpus">000581</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000581</idno><idno type="wicri:Area/Main/Curation">000581</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000581</idno><idno type="wicri:Area/Main/Exploration">000581</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Haemophilus influenzae b-vaccination: the urgency for timely vaccination.</title><author><name sortKey="Von Kries, R" sort="Von Kries, R" uniqKey="Von Kries R" first="R" last="Von Kries">R. 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Windfuhr</name></author></analytic><series><title level="j">European journal of pediatrics</title><idno type="ISSN">0340-6199</idno><imprint><date when="1997" type="published">1997</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Child, Preschool</term><term>Female</term><term>Germany (epidemiology)</term><term>Haemophilus influenzae</term><term>Humans</term><term>Immunization Schedule</term><term>Immunization, Secondary</term><term>Infant</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Logistic Models</term><term>Male</term><term>Odds Ratio</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (épidémiologie)</term><term>Analyse de variance</term><term>Calendrier vaccinal</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (épidémiologie)</term><term>Haemophilus influenzae</term><term>Humains</term><term>Modèles logistiques</term><term>Mâle</term><term>Nourrisson</term><term>Odds ratio</term><term>Rappel de vaccin</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Germany</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Child, Preschool</term><term>Female</term><term>Haemophilus influenzae</term><term>Humans</term><term>Immunization Schedule</term><term>Immunization, Secondary</term><term>Infant</term><term>Logistic Models</term><term>Male</term><term>Odds Ratio</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de variance</term><term>Calendrier vaccinal</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Grippe humaine</term><term>Haemophilus influenzae</term><term>Humains</term><term>Modèles logistiques</term><term>Mâle</term><term>Nourrisson</term><term>Odds ratio</term><term>Rappel de vaccin</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Allemagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>UNLABELLED</b></p><p>In Germany the annual number of systemic Haemophilus influenzae cases in unvaccinated children aged 3-60 months has recently been exceeded by the number of cases in children vaccinated at least once with the PRP-D, HbOC or OMP vaccines, which until 1995 have almost exclusively been used for H. influenzae b (Hib) vaccination. Most of the vaccinated children however could already have had more vaccinations at onset of disease. How much does an age-related suboptimal vaccination status increase the risk for systemic H. influenzae infections? A case control study was performed in West Germany. Cases with systemic H. influenzae infections were ascertained between 7/92 and 8/ 94 with an ongoing active hospital surveillance programme. Six age-matched population controls per case were recruited at random. Only vaccinated cases and controls were included in the study. The main exposure analysed in this study was suboptimal vaccination at censoring; for censoring ages (age at disease onset in cases and corresponding age in matched controls) > 6 months: one vaccination in 1st year only; > 18 months: two (three for combined vaccines with Hib + DT or DPT in one syringe) vaccinations in the 1st year of life but no booster vaccination. Suboptimal vaccination for age increased the risk for systemic H. influenzae infections by a factor of 4.74 (95%-CI 2.17-10.34). Following adjustment for confounders the odds ratio was 4.39 (95%-CI 1.74-11.07). Subgroup analyses showed that this risk was not related to the type of vaccine used. The risk for "no booster vaccination" in children aged > 18 months appeared even greater than the risk associated with one vaccination in the 1st year only.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>On schedule and complete Hib vaccinations are essential for an optimal effectiveness of Hib vaccination programmes. Booster vaccinations between 12 and 18 months are important if the PRP-D, HbOC and OMP vaccines are used for primary vaccination.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9128812</PMID><DateCompleted><Year>1997</Year><Month>07</Month><Day>03</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0340-6199</ISSN><JournalIssue CitedMedium="Print"><Volume>156</Volume><Issue>4</Issue><PubDate><Year>1997</Year><Month>Apr</Month></PubDate></JournalIssue><Title>European journal of pediatrics</Title><ISOAbbreviation>Eur. J. Pediatr.</ISOAbbreviation></Journal><ArticleTitle>Haemophilus influenzae b-vaccination: the urgency for timely vaccination.</ArticleTitle><Pagination><MedlinePgn>282-7</MedlinePgn></Pagination><Abstract><AbstractText Label="UNLABELLED">In Germany the annual number of systemic Haemophilus influenzae cases in unvaccinated children aged 3-60 months has recently been exceeded by the number of cases in children vaccinated at least once with the PRP-D, HbOC or OMP vaccines, which until 1995 have almost exclusively been used for H. influenzae b (Hib) vaccination. Most of the vaccinated children however could already have had more vaccinations at onset of disease. How much does an age-related suboptimal vaccination status increase the risk for systemic H. influenzae infections? A case control study was performed in West Germany. Cases with systemic H. influenzae infections were ascertained between 7/92 and 8/ 94 with an ongoing active hospital surveillance programme. Six age-matched population controls per case were recruited at random. Only vaccinated cases and controls were included in the study. The main exposure analysed in this study was suboptimal vaccination at censoring; for censoring ages (age at disease onset in cases and corresponding age in matched controls) > 6 months: one vaccination in 1st year only; > 18 months: two (three for combined vaccines with Hib + DT or DPT in one syringe) vaccinations in the 1st year of life but no booster vaccination. Suboptimal vaccination for age increased the risk for systemic H. influenzae infections by a factor of 4.74 (95%-CI 2.17-10.34). Following adjustment for confounders the odds ratio was 4.39 (95%-CI 1.74-11.07). Subgroup analyses showed that this risk was not related to the type of vaccine used. The risk for "no booster vaccination" in children aged > 18 months appeared even greater than the risk associated with one vaccination in the 1st year only.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">On schedule and complete Hib vaccinations are essential for an optimal effectiveness of Hib vaccination programmes. Booster vaccinations between 12 and 18 months are important if the PRP-D, HbOC and OMP vaccines are used for primary vaccination.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>von Kries</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Social Paediatrics, Kinderzentrum München, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Böhm</LastName><ForeName>O</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Windfuhr</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Eur J Pediatr</MedlineTA><NlmUniqueID>7603873</NlmUniqueID><ISSNLinking>0340-6199</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N" Type="Geographic">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006193" MajorTopicYN="Y">Haemophilus influenzae</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007115" MajorTopicYN="Y">Immunization Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007117" MajorTopicYN="N">Immunization, Secondary</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1997</Year><Month>4</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1997</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1997</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9128812</ArticleId><ArticleId IdType="doi">10.1007/s004310050601</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Bohm, O" sort="Bohm, O" uniqKey="Bohm O" first="O" last="Böhm">O. Böhm</name><name sortKey="Windfuhr, A" sort="Windfuhr, A" uniqKey="Windfuhr A" first="A" last="Windfuhr">A. Windfuhr</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Von Kries, R" sort="Von Kries, R" uniqKey="Von Kries R" first="R" last="Von Kries">R. Von Kries</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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